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BlueCALM™ – Extract for promoting relaxation BlueCALM™ – Extract for promoting relaxation
Written by Tina Shafiei-Birkhofer
01.09.2022

BlueCALM™ – Extract for promoting relaxation

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BlueCALM™ – Extract for promoting relaxation

Markus Sierigk

Head of Business Unit Pharma

IMPAG AG

+41 43 499 25 61E-mail LinkedIn

Blue skullcap (Scutellaria lateriflora L.) is a perennial herb native to North America that has long been used traditionally to relieve anxiety and improve mood. Recent studies suggest it has neuroprotective and anxiolytic effects.

The dry extract BlueCALM™ is obtained from Scutellaria lateriflora L. and contains 10% baicalin. BlueCALM™ is also rich in various components that are known for their biological properties: 

  • Flavonoids (baicalin, baicalein, wogonoside, wogonin)
  • Diterpenoids (scutelaterin A, B, and C)
  • Phenylpropanoids (caffeic acid, cinnamic acid, coumaric acid, ferulic acid)
  • Essential oils (terpenoids)
  • Amino acids and melatonin

 

Antioxidant properties
BlueCALM™ has strong antioxidant properties that show a significant, concentration-dependent action against free radicals in various trial models.

 

Anti-glycation action
An in-vitro study shows that BlueCALM™ inhibits the onset of AGEs (advanced glycation end products). AGEs are harmful substances produced when sugars become combined with proteins and fats, and are implicated in the aging process as well as the onset of many chronic degenerative diseases (such as Alzheimer’s).
The results of the study corroborate the neuroprotective action of Scutellaria lateriflora L., which has already been described in the available scientific literature. 

 

Efficacy against mild anxiety and insomnia
BlueCALM™ has also been tested on a human adrenocortical carcinoma cell line. This is an in-vitro model commonly used to study the mechanism of action of molecules that exhibit anti-anxiety actions.
The results show that BlueCALM™ significantly inhibits the release of the most important endogenous stress hormone cortisol. Based on this study, it can be concluded that BlueCALM™ counteracts mild states of anxiety and insomnia. 

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